Armed with some data from our friends at CrunchBase, I broke down the largest US startup funding rounds from March 2025. I have included some additional information such as industry, company description, round type, founders, and total equity funding raised to further the analysis.
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11. Lila Sciences $200.0M
Round: SeedDescription: Cambridge-based Lila Sciences creates a scientific superintelligence platform and autonomous labs for life sciences, chemistry, and materials science. Founded by Molly Gibson and Noubar Afeyan in 2023, Lila Sciences has now raised a total of $200.0M in total equity funding and is backed by General Catalyst, Modi Ventures, Flagship Pioneering, March Capital, and Abu Dhabi Investment Authority.Investors in the round: Abu Dhabi Investment Authority, Altitude Life Science Ventures, ARK Venture Fund, Blue Horizon Advisors, Flagship Pioneering, General Catalyst, March Capital, Modi Ventures, State of Michigan Retirement SystemIndustry: Artificial Intelligence (AI), Life Science, SoftwareFounders: Molly Gibson, Noubar AfeyanFounding year: 2023Location: CambridgeTotal equity funding raised: $200.0M
10. Shield AI $240.0M
Round: Series FDescription: San Diego-based Shield AI is a deep-tech company that focuses on developing AI-powered systems to enhance the safety of service members and civilians. Founded by Andrew Reiter, Brandon Tseng, and Ryan Tseng in 2015, Shield AI has now raised a total of $1.0B in total equity funding and is backed by Andreessen Horowitz, Founder Collective, Riot Ventures, US Innovative Technology Fund, and Bloomberg Beta.Investors in the round: Andreessen Horowitz, Cacti, Hanwha Aerospace, L3Harris Technologies, US Innovative Technology Fund, Washington Harbour PartnersIndustry: Artificial Intelligence (AI), Autonomous Vehicles, Drones, Machine Learning, National SecurityFounders: Andrew Reiter, Brandon Tseng, Ryan TsengFounding year: 2015Location: San DiegoTotal equity funding raised: $1.0B
9. Celestial AI $250.0M
Round: Series CDescription: Santa Clara-based Celestial AI develops an optical interconnect technology platform for data center and AI computing solutions. Founded by David Lazovsky, Michelle Tomasko, and Preet Virk in 2020, Celestial AI has now raised a total of $588.9M in total equity funding and is backed by BlackRock, Temasek Holdings, Tiger Global Management, US Innovative Technology Fund, and Fidelity.Investors in the round: AMD Ventures, BlackRock, Engine Ventures, Fidelity, Koch Disruptive Technologies, Lip-Bu Tan, Maverick Silicon, Porsche Automobil Holding, Temasek Holdings, Tiger Global Management, Xora InnovationIndustry: Artificial Intelligence (AI), Data Center, Machine Learning, Semiconductor, SoftwareFounders: David Lazovsky, Michelle Tomasko, Preet VirkFounding year: 2020Location: Santa ClaraTotal equity funding raised: $588.9M
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9. Epirus $250.0M
Round: Series DDescription: Torrance-based Epirus builds directed energy and power management systems to solve some of the world’s most complex problems. Founded by Bo Marr, Grant Verstandig, Joe Lonsdale, John Tenet, Max Mednik, and Nathan Mintz in 2018, Epirus has now raised a total of $537.4M in total equity funding and is backed by National Science Foundation, StepStone Group, 8VC, Gaingels, and I Squared Capital.Investors in the round: 8VC, Anchor Capital GP, Centaurus Capital, Center15 Capital, Gaingels, General Dynamics Land Systems, Manhattan Venture Partners (MVP), NightDragon, Oppenheimer & Co., Protagonist, StepStone Group, T. Rowe Price, Washington Harbour PartnersIndustry: Aerospace, Machinery Manufacturing, Military, SoftwareFounders: Bo Marr, Grant Verstandig, Joe Lonsdale, John Tenet, Max Mednik, Nathan MintzFounding year: 2018Location: TorranceTotal equity funding raised: $537.4M
8. Island $250.0M
Round: Series EDescription: Dallas-based Island offers an enterprise browser that enhances security and productivity by integrating essential tools. Founded by Dan Amiga and Michael Fey in 2020, Island has now raised a total of $810.0M in total equity funding and is backed by Sequoia Capital, Insight Partners, Cisco Investments, Coatue, and Canapi Ventures.Investors in the round: Canapi Ventures, Coatue, Cyberstarts, Georgian, Insight Partners, Sequoia CapitalIndustry: Cyber Security, Enterprise Software, Information Technology, Web BrowsersFounders: Dan Amiga, Michael FeyFounding year: 2020Location: DallasTotal equity funding raised: $810.0M
7. Flock Safety $275.0M
Round: Series FDescription: Atlanta-based Flock Safety provides end-to-end surveillance solutions to support law enforcement and communities. Founded by Garrett Langley and Matt Feury in 2017, Flock Safety has now raised a total of $655.6M in total equity funding and is backed by Y Combinator, Andreessen Horowitz, Founders Fund, Spark Capital, and Kleiner Perkins.Investors in the round: Andreessen Horowitz, Bedrock, Founders Fund, Greenoaks, Kleiner Perkins, Matrix, Meritech Capital Partners, Sands Capital Ventures, Tiger Global Management, Y CombinatorIndustry: Manufacturing, Public Safety, Security, SensorFounders: Garrett Langley, Matt FeuryFounding year: 2017Location: AtlantaTotal equity funding raised: $655.6M
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6. Mercury $300.0M
Round: Series CDescription: San Francisco-based Mercury provides online banking solutions for startups and technology-focused businesses. Founded by Immad Akhund, Jason Zhang, and Max Tagher in 2017, Mercury has now raised a total of $452.2M in total equity funding and is backed by Andreessen Horowitz, Sequoia Capital, Spark Capital, 500 Global, and Coatue.Investors in the round: Andreessen Horowitz, Coatue, CRV, Marathon Management Partners, Sequoia Capital, Spark CapitalIndustry: Banking, Financial Services, FinTech, Information Technology, InsurTechFounders: Immad Akhund, Jason Zhang, Max TagherFounding year: 2017Location: San FranciscoTotal equity funding raised: $452.2M
5. Fleetio $450.0M
Round: Series DDescription: Birmingham-based Fleetio is a fleet maintenance management software that helps businesses manage their fleet operations and optimize maintenance workflows. Founded by Tony Summerville in 2011, Fleetio has now raised a total of $620.1M in total equity funding and is backed by Endeavor Catalyst, Bossa Invest, Elephant, and Goldman Sachs Alternatives.Investors in the round: Elephant, Goldman Sachs AlternativesIndustry: Automotive, Fleet Management, SaaS, SoftwareFounders: Tony SummervilleFounding year: 2011Location: BirminghamTotal equity funding raised: $620.1M
4. Nerdio $500.0M
Round: Series CDescription: Chicago-based Nerdio offers cloud solutions to streamline IT management, focusing on Microsoft Azure and virtual desktop optimization. Founded by Joseph Landes and Vadim Vladimirskiy in 2016, Nerdio has now raised a total of $625.0M in total equity funding and is backed by General Atlantic, StepStone Group, Lead Edge Capital, Updata Partners, and MK Capital.Investors in the round: General Atlantic, Lead Edge Capital, StepStone GroupIndustry: Cloud Computing, Information Services, Information Technology, SoftwareFounders: Joseph Landes, Vadim VladimirskiyFounding year: 2016Location: ChicagoTotal equity funding raised: $625.0M
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3. X (formerly Twitter) $1.0B
Round: VentureDescription: Bastrop-based X is a social networking platform that allows its users to send and read microblogs. Founded by Biz Stone and Jack Dorsey in 2006, X (formerly Twitter) has now raised a total of $12.1B in total equity funding and is backed by Andreessen Horowitz, Sequoia Capital, Insight Partners, Union Square Ventures, and Slow Ventures.Investors in the round: 1789 Capital, Bossa Invest, Darsana Capital Partners, Elon Musk, Manhattan Venture Partners (MVP)Industry: Blogging Platforms, Social Media, Social Network, Web3Founders: Biz Stone, Jack DorseyFounding year: 2006Location: BastropTotal equity funding raised: $12.1B
2. Anthropic $3.5B
Round: Series EDescription: San Francisco-based Anthropic is an AI research company that focuses on the safety and alignment of AI systems with human values. Founded by Daniela Amodei, Dario Amodei, Jack Clark, Sam McCandlish, and Tom Brown in 2021, Anthropic has now raised a total of $12.9B in total equity funding and is backed by General Catalyst, Menlo Ventures, Lightspeed Venture Partners, Bessemer Venture Partners, and Google.Investors in the round: Bessemer Venture Partners, Cisco Investments, D1 Capital Partners, Fidelity, General Catalyst, Jane Street Capital, Lightspeed Venture Partners, Menlo Ventures, Salesforce VenturesIndustry: Artificial Intelligence (AI), Generative AI, Information Technology, Machine LearningFounders: Daniela Amodei, Dario Amodei, Jack Clark, Sam McCandlish, Tom BrownFounding year: 2021Location: San FranciscoTotal equity funding raised: $12.9B
1. OpenAI $40.0B
Round: VentureDescription: San Francisco-based OpenAI creates artificial intelligence technologies to assist with tasks and provide support for human activities. Founded by Andrej Karpathy, Durk Kingma, Elon Musk, Greg Brockman, Ilya Sutskever, John Schulman, Pamela Vagata, Sam Altman, Trevor Blackwell, Vicki Cheung, and Wojciech Zaremba in 2015, OpenAI has now raised a total of $57.6B in total equity funding and is backed by Andreessen Horowitz, Y Combinator, NVIDIA, Sequoia Capital, and HSBC.Investors in the round: Altimeter Capital, Coatue, Microsoft, SoftBank, Thrive CapitalIndustry: Artificial Intelligence (AI), Generative AI, Machine Learning, Natural Language Processing, SaaSFounders: Andrej Karpathy, Durk Kingma, Elon Musk, Greg Brockman, Ilya Sutskever, John Schulman, Pamela Vagata, Sam Altman, Trevor Blackwell, Vicki Cheung, Wojciech ZarembaFounding year: 2015Location: San FranciscoTotal equity funding raised: $57.6B
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